Depends. Atl+Tab isn't working in OpenGL 4.5 titles very well - at least for me. I sometimes get horrible artefacts...
Still, i'm happy with CS5 and those are working with Wine 2.3 actually pretty decent. Lightroom has some issues and i believe Illustrator also (however, i'm not using the latter). Premier runs okay-ish, had some Audio issues, but since I'm using Arch(or Antergos) they have been gone since the last update roll. But since i did not try Plugins...no idea
However, i agree. Metro Redux does run exceptionally well on OpenGL 4.5 (i have around 10 FPS less, playing at 1440p and max. Quality which equates to around 40-50 FPS).
And since Cloud Imperium Games announced they will also switch to Vulkan down the line for Star Citizen, the recent switch to the Lumberyard engine and Amazon in the back...i'm actually quite optimistic, that we're going to see Vulkan games popping up more and more. (Not to mention Dota 2, Doom and some others...also Valve will ONLY use Vulkan for the future and has ditched DX12 completely...)